12 research outputs found
Analysis of Competitiveness of Provincial Agricultural Products E-commerce Logistics Based on Information Ecological Niche Measurement
The logistics problem is the key issue that restricts the development of agricultural products e-commerce. Through the analysis of the competitiveness of agricultural products e-commerce logistics, the advantages and disadvantages of the development of agricultural products e-commerce in the region can be obtained, and the suggestions and countermeasures for adapting to the development of the region are proposed. This paper applies the information Ecological niche breadth measurement method to measure the e-commerce logistics index of agricultural products in each province, and takes Shanxi Province as an example to analyze the competitiveness of agricultural products e-commerce logistics, and proposes targeted countermeasures and suggestions
Construction of A Personalized Service Model of ABC Community Fresh E-commerce Based on Small Data
The homogenization of products and services in the development of community fresh e-commerce is more serious, and providing personalized services to community customers has become a new development key point. From the perspective of small data research, this paper proposes an e-commerce service model that uses small data to provide personalized fresh products for community customers. Taking ABC community convenience store as the research object, the paper analyzes the application of community customer small data in the personalized service of community fresh convenience store to improve the loyalty and satisfaction of community customers and promote the development of community fresh e-commerce
Facile Fabrication of Superhydrophobic Cross-Linked Nanocellulose Aerogels for Oil–Water Separation
A facile and environmental-friendly approach was developed for the preparation of the cross-linked nanocellulose aerogel through the freeze-drying process and subsequent esterification. The as-prepared aerogel had a three-dimensional cellular microstructure with ultra-low density of 6.05 mg·cm−3 and high porosity (99.61%). After modifying by chemical vapor deposition (CVD) with hexadecyltrimethoxysilane (HTMS), the nanocellulose aerogel displayed stable super-hydrophobicity and super-oleophilicity with water contact angle of 151°, and had excellent adsorption performance for various oil and organic solvents with the adsorption capacity of 77~226 g/g. Even after 30 cycles, the adsorption capacity of the nanocellulose aerogel for chloroform was as high as 170 g/g, indicating its outstanding reusability. Therefore, the superhydrophobic cross-linked nanocellulose aerogel is a promising oil adsorbent for wastewater treatment
Synthesis and Properties of Tung Oil-Based Unsaturated Co-Ester Resins Bearing Steric Hindrance
New tung oil (TO)-based, unsaturated, co-ester (Co-UE) macromonomers bearing steric hindrance were synthesized by modifying a TO-based maleate (TOPERMA) monomer with an anhydride structure with hydroxyethyl methacrylate (HEMA) and methallyl alcohol (MAA), respectively. The obtained Co-UE monomers (TOPERMA-HEMA and TOPERMA-MAA) were then characterized by 1H NMR and gel permeation chromatography (GPC). For comparison, hydroxyethyl acrylate (HEA)-modified TOPERMA (TOPERMA-HEA) was also synthesized and characterized. Subsequently, the obtained Co-UEs were thermally cured with styrene, and the ultimate properties of the resulting materials were studied. It was found that by introducing the structure of steric hindrance into the TO-based Co-UE monomer, the tensile strength and Young’s modulus of the resulting materials were improved. Furthermore, by reducing the length of the flexible chain in the Co-UE monomer, the tensile strength, Young’s modulus, and glass transition temperature (Tg) of the resultant materials were also improved. The TOPERMA-MAA resin gave the best performance in these TO-based Co-UE resins, which showed a tensile strength of 32.2 MPa, Young’s modulus of 2.38 GPa, and Tg of 130.3 °C. The developed ecofriendly materials show promise in structural plastic applications
Tung Oil-Based Unsaturated Co-ester Macromonomer for Thermosetting Polymers: Synergetic Synthesis and Copolymerization with Styrene
A novel
unsaturated co-ester (co-UE) macromonomer containing both
maleates and acrylates was synthesized from tung oil (TO) and its
chemical structure was characterized by FT-IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and gel permeation chromatography (GPC). The monomer
was synthesized via a new synergetic modification of TO, by introducing
maleic groups first and acrylic groups subsequently onto TO molecules.
The influence of experimental factors on thermomechanical properties
of the cured bioresins was evaluated to better understand structure–property
relationships of the biomaterials and optimize experimental conditions.
The obtained TO-based co-UE monomer possessed a highly polymerizable
Cî—»C functionality, consequently resulting in rigid bioplastics
with high cross-link densities (ν<sub>e</sub>) and excellent
mechanical properties. For instance, the bioplastic prepared under
the optimal synthesis conditions demonstrated a ν<sub>e</sub> of 4.03 × 10<sup>3</sup> mol/m<sup>3</sup>, storage modulus
at 25 °C of 2.40 GPa, and glass transition temperature (<i>T</i><sub>g</sub>) of 127 °C, as well as tensile strength
and modulus at 36.3 MPa and 1.70 GPa, respectively. A new theory for
determining optimal comonomer concentration was further developed
according to the copolymerization equation. The proposed theory accurately
predicted the best styrene dosage for the co-UE monomer. At last,
the hydroxyethyl acrylate (HEA)-modified TO-based resin was compared
with the unmodified one in thermomechanical properties, thermal stability,
microstructural morphologies, and curing behaviors. The new co-UE
bioresin showed higher Cî—»C functionality and cross-link density,
superior properties including <i>T</i><sub>g</sub> and thermal
stability, and similar curing behaviors. The developed eco-friendly
rigid biomaterials provide potential application in structural plastics
such as sheet molding compounds
Highly Functional Unsaturated Ester Macromonomer Derived from Soybean Oil: Synthesis and Copolymerization with Styrene
A highly functional unsaturated ester
macromonomer was synthesized
from soybean oil (SBO), and its chemical structure was confirmed by
FT-IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and gel permeation chromatography.
The monomer was prepared through modifying epoxidized soybean oil
(ESO) first with a synthesized precursor, hydroxyethyl acrylated maleate
(HEAMA), and then employing maleic anhydride (MA) to modify the produced
ESO-HEAMA. The obtained SBO-based monomer (ESO-HEAMA-MA) possessed
a CC bond functionality of 6.75–8.15 per ESO. Effects
of styrene concentration, feed ratio, and initiator concentration
on the dynamic mechanical properties of the cured bioresins were investigated
carefully. When the monomer with the highest Cî—»C bond functionality
was used, the cured resins with 20–60 wt % styrene demonstrated
cross-link densities of 5.07–9.52 (10<sup>3</sup> mol)/m<sup>3</sup>, storage moduli at 25 °C of 1.32–2.16 GPa, glass
transition temperatures of 69.9–114.1 °C, and tensile
strengths and moduli of 19.7–33.1 MPa and 1.17–2.11
GPa, respectively. Microstructural morphologies of tensile-fractured
surfaces of the cured resins were studied by scanning electron microscopy.
Finally, curing behaviors of the resultant resin was studied by differential
scanning calorimetry. The developed eco-friendly biomaterials have
potential applications in the industry of unsaturated polyester resins
PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis
Glaucoma is the leading cause of irreversible blindness worldwide. In the pathogenesis of glaucoma, activated microglia can lead to retinal ganglion cells (RGCs) apoptosis and death, however, the molecular mechanisms remain largely unknown. We demonstrate that phospholipid scramblase 1 (PLSCR1) is a key regulator promoting RGCs apoptosis and their clearance by microglia. As evidenced in retinal progenitor cells and RGCs of the acute ocular hypertension (AOH) mouse model, overexpressed PLSCR1 induced its translocation from the nucleus to the cytoplasm and cytomembrane, as well as elevated phosphatidylserine exposure and reactive oxygen species generation with subsequent RGCs apoptosis and death. These damages were effectively attenuated by PLSCR1 inhibition. In the AOH model, PLSCR1 led to an increase in M1 type microglia activation and retinal neuroinflammation. Upregulation of PLSCR1 resulted in strongly elevated phagocytosis of apoptotic RGCs by activated microglia. Taken together, our study provides important insights linking activated microglia to RGCs death in the glaucoma pathogenesis and other RGC-related neurodegenerative diseases
A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection
BACKGROUND: In kidney transplant recipients, surveillance biopsies can reveal, despite stable graft function, histologic features of acute rejection and borderline changes that are associated with undesirable graft outcomes. Noninvasive biomarkers of subclinical acute rejection are needed to avoid the risks and costs associated with repeated biopsies. METHODS: We examined subclinical histologic and functional changes in kidney transplant recipients from the prospective Genomics of Chronic Allograft Rejection (GoCAR) study who underwent surveillance biopsies over 2 years, identifying those with subclinical or borderline acute cellular rejection (ACR) at 3 months (ACR-3) post-transplant. We performed RNA sequencing on whole blood collected from 88 individuals at the time of 3-month surveillance biopsy to identify transcripts associated with ACR-3, developed a novel sequencing-based targeted expression assay, and validated this gene signature in an independent cohort. RESULTS: Study participants with ACR-3 had significantly higher risk than those without ACR-3 of subsequent clinical acute rejection at 12 and 24 months, faster decline in graft function, and decreased graft survival in adjusted Cox analysis. We identified a 17-gene signature in peripheral blood that accurately diagnosed ACR-3, and validated it using microarray expression profiles of blood samples from 65 transplant recipients in the GoCAR cohort and three public microarray datasets. In an independent cohort of 110 transplant recipients, tests of the targeted expression assay on the basis of the 17-gene set showed that it identified individuals at higher risk of ongoing acute rejection and future graft loss. CONCLUSIONS: Our targeted expression assay enabled noninvasive diagnosis of subclinical acute rejection and inflammation in the graft and may represent a useful tool to risk-stratify kidney transplant recipients.status: publishe
A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection
BACKGROUND: In kidney transplant recipients, surveillance biopsies can reveal, despite stable graft function, histologic features of acute rejection and borderline changes that are associated with undesirable graft outcomes. Noninvasive biomarkers of subclinical acute rejection are needed to avoid the risks and costs associated with repeated biopsies.
METHODS: We examined subclinical histologic and functional changes in kidney transplant recipients from the prospective Genomics of Chronic Allograft Rejection (GoCAR) study who underwent surveillance biopsies over 2 years, identifying those with subclinical or borderline acute cellular rejection (ACR) at 3 months (ACR-3) post-transplant. We performed RNA sequencing on whole blood collected from 88 individuals at the time of 3-month surveillance biopsy to identify transcripts associated with ACR-3, developed a novel sequencing-based targeted expression assay, and validated this gene signature in an independent cohort.
RESULTS: Study participants with ACR-3 had significantly higher risk than those without ACR-3 of subsequent clinical acute rejection at 12 and 24 months, faster decline in graft function, and decreased graft survival in adjusted Cox analysis. We identified a 17-gene signature in peripheral blood that accurately diagnosed ACR-3, and validated it using microarray expression profiles of blood samples from 65 transplant recipients in the GoCAR cohort and three public microarray datasets. In an independent cohort of 110 transplant recipients, tests of the targeted expression assay on the basis of the 17-gene set showed that it identified individuals at higher risk of ongoing acute rejection and future graft loss.
CONCLUSIONS: Our targeted expression assay enabled noninvasive diagnosis of subclinical acute rejection and inflammation in the graft and may represent a useful tool to risk-stratify kidney transplant recipients